TEST METHODS FOR PREDICTING TARDIVE TOXICITY OF THERAPEUTIC DRUGS USING LABORATORY ANIMALS
نویسندگان
چکیده
منابع مشابه
development of different optical methods for determination of glucose using cadmium telluride quantum dots and silver nanoparticles
a simple, rapid and low-cost scanner spectroscopy method for the glucose determination by utilizing glucose oxidase and cdte/tga quantum dots as chromoionophore has been described. the detection was based on the combination of the glucose enzymatic reaction and the quenching effect of h2o2 on the cdte quantum dots (qds) photoluminescence.in this study glucose was determined by utilizing glucose...
Toxicity Screening of Therapeutic Drugs
INTRODUCTION In the course of in vitro systems search for the toxicity screening of therapeutic drugs (TDs), different cellular models have been applied to examine their adverse effects in isolated organs. This article describes a simple method to determine effects of TDs at the cell membrane level. The cell membrane is an assembly of proteins and lipids that separate inside from outside, prote...
متن کاملAssessment of testicular toxicity in laboratory animals
The currently available methods of assessing testicular toxicity and fertility are discussed. Compounds inducing testicular atrophy mainly affect the seminiferous epithelium, with progressive loss of spermatozoa, spermatids, spermatocytes, and spermatogonia. Quantitative histometric analysis of spermatogenesis, together with hormone assays, could be used to advantage in defining the underlying ...
متن کاملProblems in extrapolating toxicity data for laboratory animals to man.
Some of the problems in extrapolating laboratory animal toxicity data to man are considered. The quantitative predictiveness of preclinical studies of anticancer drugs using dogs and monkeys for man has also been examined. The relationship between the maximum tolerated dose (MTD) in the dog, monkey, and the more sensitive of the two species and clinical observations are discussed. The effective...
متن کاملusing c-test passages for improving reading comprehension ability and incidentally learned vocabulary of iranian efl learners
this study was an attempt to investigate the effect of using c-test passages on the reading comprehension and incidental vocabulary learning of iranian intermediate efl learners. the participants were 60 male efl learners at kish mehr institute in garmsar. in fact, there were two groups, an experimental group and a comparison group with 30 students in each. the participants were pretested throu...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1996
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.21.105